Neglected Tropical Diseases

Neglected Tropical Diseases

Neglected tropical diseases (NTDs) are a set of 17 diseases that disproportionately affect more than 1 billion people living primarily in the developing world.

 

As a leading cause of disability, NTDs carry with them significant social and economic burdens. However, as the World Health Organization (WHO) reports, many of these diseases can be effectively controlled, and in many cases, eliminated. Our company has a long-standing commitment to research into NTDs. We initiated research on MECTIZAN® (ivermectin) for use in humans for the NTD onchocerciasis (river blindness) in 1978, leading to the creation of the groundbreaking MECTIZAN Donation Program. Through a range of in-house programs and external partnerships, we continue to conduct research to address the burden of neglected tropical diseases today. Learn more about the MECTIZAN Donation Program.

THE LONDON DECLARATION

We are an original signatory to the London Declaration, a collaborative effort launched in 2012 to accelerate progress toward eliminating or controlling 10 NTDs by the end of the decade. Our company joined 12 other global pharmaceutical companies and many other stakeholders, including endemic country governments, the WHO, the Bill & Melinda Gates Foundation, the U.S. Agency for International Development (USAID), the UK Department for International Development (DFID), nongovernmental organizations (NGOs) and other organizations in this effort.

Together with the other pharmaceutical companies, we committed to continuing or increasing donations of medicines to treat or prevent these diseases. Donors committed financial resources, and NGOs agreed to support implementation needs. The partners came together under the banner of “Uniting to Combat NTDs” to track progress and identify gaps that need to be addressed in order to reach the goals of the London Declaration. Through the MECTIZAN Donation Program, we are helping to achieve the disease control and elimination goals for two diseases, onchocerciasis (river blindness) and lymphatic filariasis (LF).

Although existing tools are having a major impact, several NTDs require new or improved drugs and diagnostics to achieve the goals of the London Declaration. We are engaged in various efforts to advance progress toward developing new drugs and diagnostics. For example, together with several other companies, we are providing access to compound libraries with external researchers through the World Intellectual Property Organization’s Re:Search (WIPO Re:Search) Consortium and Drugs for Neglected Disease Initiative (DNDi). Learn more about our social licensing approach to combatting NTDs.

Taken together, through our drug donations for onchocerciasis and LF and our research and development activities for schistosomiasis, visceral leishmaniasis (VL) and Chagas disease, we are supporting the London Declaration goals for five NTDs.

For more information on progress toward the London Declaration goals, click here.

For more information on our company’s drug donations for onchocerciasis and LF, please refer to the MECTIZAN Donation Program.

RESEARCH & DEVELOPMENT

WIPO Re:Search

Our company is one of the founding members of WIPO Re:Search, a consortium of public and private organizations that facilitates research on neglected tropical diseases, malaria and tuberculosis. Through this consortium, we entered into an agreement with researchers at the University of California, San Francisco (UCSF), which was later transferred to the University of California, San Diego (UCSD), providing scientists with a series of compounds for screening that have the potential to lead to better and safer treatments for patients suffering from schistosomiasis. This disease is caused by a blood-borne parasite, and affects millions of people living in the developing world.

Also through WIPO Re:Search, in late 2014 we entered into an agreement with researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Australia that supports collaboration focused on the research and development of antimalarial drugs that could potentially impact the replication and transmission of malaria. In 2015, our joint team was successful in applying for and receiving a Wellcome Trust Pathfinder Award. The joint team leveraged this award to characterize and advance two separate series of hits to the point where an application for the next phase of funding has been submitted. It is anticipated that this program will achieve lead optimization status in 2018.

In furtherance of our commitment to the WIPO Re:Search mission and community, we continue to provide relevant expertise to other WIPO Re:Search members as requested and appropriate. We also continue to consider other collaboration opportunities where our company’s contributions can provide unique and significant impact.

G-FINDER Survey

To contribute to global awareness and advocacy on research and development (R&D) for NTDs, we participate in the annual G-FINDER survey. Since 2008, G-FINDER has reported on global investments in neglected disease R&D from a range of public and private institutions, and is considered a unique source of current information and insights into ongoing trends for stakeholders engaged in NTDs. We are pleased to note that in this year’s G-FINDER report, private investment in neglected disease R&D in 2015—in both absolute terms, and as a proportion of global funding—was the highest ever recorded in the history of the G-FINDER survey as a result of the combined contributions of our company and other private sector contributors.

DNDi Collaboration

In May 2009, our company and the nonprofit organization DNDi entered into a collaboration to support the discovery and development of improved treatments for a range of NTDs. The initial partnership focused on trypanosome-derived NTDs, including VL and Chagas disease, both of which infect millions of people. We have recently expanded this partnership for 2016 to include the investigation of macrofilaricidal agents (compounds that would kill adult worms that cause onchocerciasis and LF) that would feed into further development activities conducted under the umbrella of the Bill & Melinda Gates Foundation–driven Macrofilaricide Drug Accelerator consortium described below.

Through a nonexclusive, royalty-free license to DNDi, we are contributing small-molecule assets and related intellectual property for DNDi to conduct early-development programs for drug candidates for treatment of NTDs, with the primary goal of manufacturing and distributing drugs at low cost to the public sector in resource-poor countries. In the anti-trypanosome effort, we have identified several series relevant for NTD indications, three of which displayed early promise and moved into in vivo studies. Unfortunately, all three failed to meet predetermined criteria for advancement. At least one additional series is moving into in vivo validation studies that are initiating during 2017 or are being planned.

For the macrofilaricide effort, we identified promising lead series with activity in a whole-worm assay. These leads were included in a compound collection that also included advanced compounds designed to allow rapid progression to in vivo efficacy studies. We continue to offer resources to enable DNDi’s macrofilaricide efforts to identify and advance promising candidates. For all of our efforts with DNDi, we will share joint intellectual property rights on drug candidates generated through early development, and our company will retain the option to undertake late clinical development and registration of these drugs.

Macrofilaricide Drug Accelerator

In 2015, our company became a founding member of the Macrofilaricide Drug Accelerator Program (MacDA), an effort driven by the Bill & Melinda Gates Foundation to support the members’ collective work toward identifying and generating lead drug compounds to augment the global onchocerciasis and LF drug pipelines. We have established collaborations within the MacDA membership in support of the program’s goals to accelerate the discovery of such lead drug compounds.

DNDi also is a key player in this effort, assisting us in the evaluation of lead molecules. This work has led to the identification of several promising lead series with activity in a whole-worm assay. These leads were included in a compound collection that also included advanced compounds designed to allow rapid progression to in vivo efficacy studies. In 2016, three different classes of our compounds were moved to in vivo proof-of-concept studies directed by DNDi, but unfortunately all failed to meet predetermined criteria for progression. We continue to offer resources to enable DNDi’s macrofilaricide efforts to identify and advance promising candidates.

Emerging Pathogens with Potential to Generate Severe Epidemics

We are currently collaborating with the United States Army Medical Research Institute of Infectious Diseases and other organizations on research to determine the ability of our company’s compounds and biologics to inhibit infectious disease organisms, including Ebola, Zika and related viruses that have the potential to generate severe epidemics and pose a threat to civilian and military populations.